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. 2016 Aug 26;10:2691–2699. doi: 10.2147/DDDT.S105718

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© 2016 Preusch et al. This work is published and licensed by Dove Medical Press Limited

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Atherosclerotic lesion composition within the aortic sinus after 25 weeks of ticagrelor treatment, 0.15% (270 mg/kg/day), starting at 20 weeks of age.

Notes: (A) Ticagrelor treatment lead to a trend in the reduction of total size of atherosclerotic lesions. However, this difference did not reach the levels of significance. Data are expressed as median and range (P=0.1). (B) Mice treated with ticagrelor showed a reduction in mean size of the necrotic core (ratio of necrotic core/total lesion area) within the atherosclerotic lesion. Data are expressed as median and range (*P=0.008). (C) Thicker fibrous caps could be observed in apoE^−/− mice treated with ticagrelor compared with chow-fed controls. Data are expressed as median and range (*P=0.04).