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. 2016 Aug 26;10:2691–2699. doi: 10.2147/DDDT.S105718

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© 2016 Preusch et al. This work is published and licensed by Dove Medical Press Limited

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Reduction of apoptosis and oxLDL uptake in RAW 264.7 cells.

Notes: (A) Incubation of RAW 264.7 cells with 0.1 μM ticagrelor leads to a significant reduction of TUNEL-positive cells. Apoptosis was induced via serum starvation for 8 hours. Data are expressed as mean ± standard deviation (*P=0.0002). (B) Incubation of RAW 264.7 cells with 0.1 μM ticagrelor beginning 4 hours prior to an oxLDL stimulation for 20 hours leads to a significant reduction of oil-red opositive granula within the cells. Data are expressed as median and range (*P=0.02).

Abbreviation: TUNEL, Terminal deoxynucleotidyl transferase dUTP nick end labeling.