Table 1.
Characteristics of patients (age>=16) with acute leukemia in remission receiving unrelated cord blood , 8/8 matched or 7/8 mismatched unrelated donor transplant, transplant reported to the CIBMTR between 2008 and 2011
| Variable | MUD N=930 N (%) |
MMUD N=283 N (%) |
UCB N=568 N (%) |
p-value | |
|---|---|---|---|---|---|
| Gender, male | 514(55%) | 141 (50%) | 267 (47%) | 0.006 | |
| Age, median (range), yrs | 48(16–78) | 47(16–73) | 43(16–72) | <0.001 | |
| Karnofsky score | 0.006 | ||||
| ≥90% | 599 (64%) | 186(66%) | 416(73%) | ||
| <90% | 309 (33%) | 93 (33%) | 145(26%) | ||
| Missing | 22 ( 2%) | 4( 1%) | 7( 1%) | ||
| Disease | <0.001 | ||||
| AML | 753(81%) | 226 (80%) | 395 (70%) | ||
| ALL | 177(19%) | 57 (20%) | 173(30%) | ||
| Disease status | 0.014 | ||||
| CR1 | 666 (72%) | 196(69%) | 366 (64%) | ||
| CR2 | 264 (28%) | 87(31%) | 202 (36%) | ||
| Conditioning intensity | 0.001 | ||||
| MAC | 690 (74%) | 202(71%) | 371 (65%) | ||
| NMA/RIC | 240 (26%) | 81 (29%) | 197(35%) | ||
| Conditioning Regimen | <0.001 | ||||
| Cy + TBI ± Other | 264 (28%) | 87(31%) | 424 (75%) | ||
| TBI ± Other | 113(12%) | 39(14%) | 51 ( 9%) | ||
| Bu + Cy ± Other | 175(19%) | 51 (18%) | 38 ( 7%) | ||
| Melphalan ± Other | 48 ( 5%) | 20 ( 7%) | 32 ( 6%) | ||
| Cy ± Other | 17 ( 2%) | 3( 1%) | 4(<1%) | ||
| Bu + Flu | 289(31%) | 78 (28%) | 15 ( 3%) | ||
| Other | 24 ( 3%) | 5 ( 2%) | 4(<1%) | ||
| GVHD prophylaxis | <0.001 | ||||
| CNI + MTX ± others | 622 (67%) | 174(61%) | 16 ( 3%) | ||
| CNI + MMF± others | 198(21%) | 74 (26%) | 472 (83%) | ||
| CNI ± others | 85 ( 9%) | 26 ( 9%) | 59(10%) | ||
| Other/UNK | 25 ( 3%) | 9 ( 3%) | 21 ( 4%) | ||
| ATG, yes | 325 (35%) | 143(50%) | 122(21%) | <0.001 | |
| Donor/Recipient CMV | <0.001 | ||||
| Pos/Pos | 224 (24%) | 86 (30%) | 0 | ||
| Pos/Neg | 99(11%) | 37(13%) | 0 | ||
| Neg/Pos | 323 (35%) | 90 (32%) | 381 (67%) | ||
| Neg/Neg | 273 (29%) | 69 (24%) | 183(32%) | ||
| Unknown | 11 ( 1%) | 1 (<1%) | 4(>1%) | ||
| G-CSF/GM-CSF, yes | 285(31%) | 91 (32%) | 488 (86%) | <0.001 | |
| Received IVIG, yes | 191 (21%) | 68 (24%) | 163(29%) | <0.001 | |
| Year of transplant | <0.001 | ||||
| 2008 | 337 (36%) | 126(45%) | 122(21%) | ||
| 2009 | 295 (32%) | 87(31%) | 152(27%) | ||
| 2010 | 180(20%) | 51 (18%) | 158(28%) | ||
| 2011 | 109(12%) | 19 ( 7%) | 136(24%) | ||