Table 4.
Results of multivariable analysis for risk of bacterial, fungal, and viral infections
| Variable | Bacterial Infections RR (95% CI) |
p-value | Fungal Infections RR (95% CI) |
p-value | Viral Infections RR (95% CI) |
p-value | |
|---|---|---|---|---|---|---|---|
| Main Effect | <0.0001 | 0.0002 | <0.0001 | ||||
| MUD | 1.00 | 1.00 | 1.00 | ||||
| MMUD | 1.196(1.018–1.406) | 0.0295 | 1.377(1.013–1.872) | 0.0413 | 1.283(1.072–1.535) | 0.0067 | |
| UCB* | 1.609(1.414–1.831) | <0.001 | 1.654(1.301 −2.102) | <0.0001 | 2.281 (1.989–2.615) | <0.0001 | |
| Acute GVHD, yes | 1.360(1.163–1.589) | 0.0001 | |||||
| Chronic GVHD, yes | 1.490(1.152–1.928) | 0.0024 | |||||
|
Conditioning regimen (< 3 mo) |
<0.0001 | ||||||
| MAC | 1.00 | ||||||
| NMA/RIC | 0.588 (0.505 – 0.683) | ||||||
|
Conditioning regimen (> 3 mo) |
0.9030 | ||||||
| MAC | 1.00 | ||||||
| NMA/RIC | 1.016(0.791 −1.304) | ||||||
| Year of Transplant | 0.0226 | ||||||
| 2008 – 2009 | 1.00 | ||||||
| 2010–2011 | 0.938(0.888–0.991) | ||||||
| ATG, yes | 1.604(1.400–1.838) | <0.0001 | |||||
| CMV D/R match | <0.0001 | ||||||
| Neg/Neg | 1.00 | ||||||
| Any positive | 1.629(1.413–1.878) | <0.001 | |||||
| Missing | 0.802(0.378–1.701) | 0.5647 | |||||
| Conditioning | 0.0002 | ||||||
| Regimen | 1.00 | ||||||
| MAC | 0.768 (0.667 – 0.883) | ||||||
| NMA/RIC | |||||||
| GVHD╪ | 0.0001 | ||||||
| aGVHD no, cGVHD no | 1.00 | ||||||
| aGVHD yes, cGVHD no | 1.863(1.601 −2.167) | <0.0001 | |||||
| aGVHD no, cGVHD yes | 2.331 (1.64–3.317) | <0.0001 | |||||
| aGVHD yes, cGVHD yes | 1.855(1.259–2.733) | 0.0018 | |||||
*
Contrast MMUD vs UCB: Bacterial, 0.74 (0.62–0.88), p<0.001; Fungal, 0.83 (0.61 – 1.14), p=0.26; Viral, 0.56 (0.47 – 0.68), p<0.0001
╪
Contrast: aGVHD yes, cGVHD no vs aGVHD no, cGVHD yes, 0.799 (0.559 – 1.14), p = 0.218; aGVHD yes, cGVHD no vs aGVHD yes, 1.004 (0.680 – 1.481), p=0.984; aGVHD no, cGVHD yes vs. aGVHD yes, cGVHD yes, 1.256 (0.834 – 1.892), p=0.275