Table 5.
Multivariable models for transplant outcomes
| Variable | Relative Risk (95% CI) |
p-value | Relative Risk (95% CI) | p-value | |
|---|---|---|---|---|---|
| Overall Survival | Leukemia Free Survival | ||||
| Graft source (KPS ≥ 90) | 0.143 | ||||
| MUD | 1.00 | 0.071 | 1.00 | ||
| MMUD | 1.269(1.026–1.571) | 0.028 | 1.221 (0.994–1.499) | 0.057 | |
| UCB* | 1.131 (0.955–1.341) | 0.155 | 1.101 (0.934–1.296) | 0.252 | |
| Graft source (KPS < 90) | <0.0001 | <0.001 | |||
| MUD | 1.00 | 1.00 | |||
| MMUD | 1.162(0.859–1.573) | 0.329 | 1.291 (0.969–1.719) | 0.081 | |
| UCB* | 1.785(1.392–2.88) | <0.0001 | 1.769(1.391 −2.251) | <0.0001 | |
| Age | <0.0001 | <0.0001 | |||
| 16–30 years | 1.00 | 1.00 | |||
| 31 – 50 years | 1.030(0.862–1.230) | 0.7483 | 0.982(0.831 −1.162) | 0.835 | |
| > 50 years╪ | 1.576(1.336–1.859) | <0.0001 | 1.374(1.174–1.608) | <0.0001 | |
| Bacterial infection, yes | 2.450(2.110–2.846) | <0.0001 | 1.724(1.512–1.965) | <0.0001 | |
| Fungal infection, yes | 3.004(2.584–3.491) | <0.0001 | 2.458(1.091 −2.888) | <0.0001 | |
| Viral Infection, yes | 1.043(0.903–1.205) | 0.5680 | |||
| Non-Relapse Mortality | Relapse | ||||
| Graft Source | 0.0006 | 0.8707 | |||
| MUD | 1.00 | 1.00 | |||
| MMUD | 1.370(1.078–1.740) | 0.0099 | 1.013(0.801 −1.282) | 0.9125 | |
| UCB* | 1.454(1.189–1.777) | 0.0003 | 1.051 (0.872–1.267) | 0.5999 | |
| Age | <0.0001 | ||||
| 16–30 years | 1.00 | ||||
| 31 – 50 years | 0.993(0.784–1.258) | 0.9557 | |||
| > 50 years* | 1.54 (1.220 – 1.979) | 0.0004 | |||
| Acute GVHD, yes | 1.257(1.052–1.501) | 0.0118 | |||
| Chronic GVHD, yes | 1.504(1.181 −1.915) | 0.0010 | |||
| Bacterial infection, yes | 3.170(2.524–3.982) | <0.0001 | |||
| Fungal infection, yes | 3.969(3.258–4.835) | <0.0001 | |||
| Viral infection, yes | 1.241 (1.024–1.505) | 0.0281 | |||
|
Conditioning regimen (≤ 3 months) |
0.0109 | ||||
| MAC | 1.00 | ||||
| NMA/RIC | 0.605(0.410–0.893) | ||||
|
Conditioning regimen (> 3 months) |
0.6844 | ||||
| MAC | 1.00 | ||||
| NMA/RIC | 0.947(0.730–1.22) | ||||
| Conditioning regimen | <0.0001 | ||||
| MAC | 1.00 | ||||
| NMA/RIC | 1.944 (1.645 – 2.296) | ||||
*
Contrast MMUD vs UCB: OS, KPS≥90% = 1.122 (0.899 – 1.400), p=0.307; OS, KPS <90% = 0.651 (0.470 – 0.903), p=0.010; LFS, KPS≥90% = 1.109 (0.896 – 1.374), p=0.341; LFS, KPS<90% = 0.729 (0.534 – 0.996), p=0.047; NRM = 0.942 (0.740 – 1.201), p=0.631; Relapse = 0.964 (0.747 – 1.244), p=0.777
╪
Contrast 31–50 yrs vs >50 yrs: OS = 0.653 (0.566 – 0.754), p<0.0001; LFS = 0.715 (0.623 – 0.820), p<0.0001; NRM = 0.639 (0.516 – 0.792), p<0.0001