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. Author manuscript; available in PMC: 2017 Feb 25.
Published in final edited form as: Nature. 2016 Aug 25;536(7617):484–487. doi: 10.1038/nature19107

Figure 4. Conserved rearrangement of residue contacts between inactive and active state structures across diverse class A GPCRs.

Figure 4

a. Illustration of the conserved rearrangement of residue contacts between inactive and active state structures in β2AR. Dotted circles around 6x37 and 7x53 denote the movement of helices 6 and 7 upon activation. b. Conservation pattern of residue contacts involved in the contact rearrangement upon receptor activation in the inactive (left) and active (right) state structures of class A GPCRs.