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. 2015 Dec 11;94(49):e2228. doi: 10.1097/MD.0000000000002228

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Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.

This is an open access article distributed under the Creative Commons Attribution-NoDerivatives License 4.0, which allows for redistribution, commercial and non-commercial, as long as it is passed along unchanged and in whole, with credit to the author. http://creativecommons.org/licenses/by-nd/4.0

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Inhibition of beta-catenin activity attenuates The Sam68-induced breast cancer stem cell renewal phenotype. (A) Western blotting analysis to confirm the knockdown or overexpression of TCF4 or LEF1 in the indicated cells. (B) Luciferase-reporter assay of TCF/LEF transcriptional activity in the indicated cells. Experiments in A to I were repeated at least 3 times with similar results; error bars in A, B, C, and D are mean ± SD. ∗P < 0.05. (C) Representative micrographs (left) and quantification (right) of mammosphere formation. (D) Detection of the proportion of SP cells by flow cytometry.