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Immunohistochemical staining of MTAP in nasopharyngeal carcinoma. Non-neoplastic nasopharyngeal epithelial tissue (A) and representative low-stage NPC (B) show intact MTAP expression. While representative high-stage NPC (C) is deficient for MTAP expression. In addition, the expression of MTAP is also present either in the lymphocytes (A and C) or stromal cells (B) adjacent to the tumor or non-neoplastic mucosa. MTAP = methylthioadenosine phosphorylase, NPC = nasopharyngeal carcinoma.
