Table 4. Adjusted effect estimates^a of patella lead, genetic score and interaction between patella lead and genetic risk score.

	N	Patella lead
Genetic Risk Score 1b,d	393	Hazard ratio	95% CI		P valuee
8–16	113	0.97	0.69	1.36	0.006
17–19	143	1.21	0.85	1.72
20–27	137	2.27	1.50	3.42
Genetic Risk Score 2c,d	444
4–9	130	0.82	0.60	1.13	<0.0001
10–12	194	1.58	1.19	2.10
13–17	120	2.77	1.78	4.31

^a Adjusted for age, BMI, smoking status (ever/never) and total cholesterol to HDL cholesterol ratio for all models;

^b Genetic risk score1 was constructed by using all 22 available SNPs in our study;

^c Genetic risk score2 was constructed by using 9 SNPs we found significantly modified the relationship between lead and incident CHD events. The 9 SNPs were VDR (rs1544410, rs7975232, rs757343), HMOX1 (rs2071746, rs2071749, rs5995098), APOE (rs429358), and AGT (rs699, rs5046).

^d Tertiles of genetic risk score with its range in each tertile. Unit for genetic risk score is one risk allele.

^e P value for interaction term between genetic risk score and patella lead levels from Wald test in the adjusted Cox proportional hazard models.