Fig. 4.

Concentration-response curves to ACh in the absence and presence of l-N^G-nitroarginine methyl ester hydrochloride (l-NAME) in WT and Cav2^−/− mice. Vasodilation increased with ACh concentration in all branch orders with no differences between groups. Vasodilation to ACh decreased significantly and to the same extent in the presence of l-NAME in all branch orders of both groups. Summary data are means ± SE; n = 6 per group. *P < 0.05 for effect of l-NAME in WT mice. #P < 0.05 for effect of l-NAME in Cav2^−/− mice.