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Endogenous activation of ChemR23 amplifies EFS-induced contraction. A and B: the ChemR23 receptor antagonist CCX832 alone reduced EFS-induced contraction in the presence, but not in the absence, of PVAT. C: the inactive congener CCX826 did not reduce EFS-induced contraction in arteries in the presence of PVAT after a 30-min incubation. Values are means ± SE; n, number of animals. *Statistically different from vehicle response within each frequency.
