Table 1.
Contraction to PE in rat superior mesenteric artery without and with PVAT before and after exposure to CCX832
| −PVAT |
+PVAT |
|||
|---|---|---|---|---|
| Initial contraction, mg | Final contraction, mg | Initial contraction, mg | Final contraction, mg | |
| Vehicle | 1,172 ± 28 | 1,294 ± 52 | 944 ± 46 | 1,191 ± 56 |
| Chemerin-9 | 909 ± 91 | 798 ± 162 | 823 ± 34 | 1,041 ± 21 |
| CCX832 | 1,149 ± 82 | 1,211 ± 88 | 913 ± 68 | 827 ± 26 |
| Chemerin-9 + CCX832 | 1,256 ± 57 | 1,408 ± 64 | 1,091 ± 112 | 994 ± 55 |
Values are means ± SE for number of animals reported in Fig. 2. Rat superior mesenteric artery without (−) and with (+) perivascular adipose tissue (PVAT) was stimulated with 10−5 M phenylephrine (PE) and exposed to chemerin-9 (1 μM), CCX832 (100 nM), or chemerin-9 + CCX832.