Table 4.
Serum concentrations of angiogenic and inflammatory factors and the percentage of circulating proangiogenic cells (CD34+CD133+) before and 30 and 120 min following exposure to lower body heating or to a control intervention (protocol 1)
| Control (33°C) |
LBH (48°C) |
|||||
|---|---|---|---|---|---|---|
| Pre | 30 min post | 120 min post | Pre | 30 min post | 120 min post | |
| TNF-α, pg/ml | 13.2 ± 2.9 | 16.6 ± 3.8 | 16.2 ± 4.2 | 15.0 ± 3.3 | 17.5 ± 4.5 | 15.2 ± 3.1 |
| IL-8, pg/ml | 34.7 ± 9.6 | 39.6 ± 10.3 | 35.1 ± 8.7 | 33.4 ± 7.7 | 34.9 ± 8.5 | 38.9 ± 8.8 |
| VEGF, pg/ml | 656.6 ± 146.8 | 747.9 ± 165.8 | 737.1 ± 149.3 | 648.5 ± 123.6 | 704.8 ± 128.5 | 685.6 ± 135.4 |
| FGF2, pg/ml | 126.0 ± 39.6 | 139.9 ± 37.8 | 137.3 ± 34.6 | 115.6 ± 28.8 | 135.2 ± 35.2 | 136.2 ± 38.4 |
| G-CSF, pg/ml | 71.5 ± 22.8 | 81.6 ± 25.3 | 83.5 ± 27.1 | 63.1 ± 18.6 | 63.9 ± 16.7 | 70.8 ± 23.9 |
| CCL2, pg/ml | 666.1 ± 40.2 | 507.8 ± 36.0 | 504.1 ± 36.9 | 670.0 ± 48.1 | 511.2 ± 36.2 | 500.3 ± 35.9 |
| ET-1, pg/ml | 1.1 ± 0.06 | 1.5 ± 0.09 | 1.6 ± 0.1 | 1.2 ± 0.08 | 1.0 ± 0.08* | 1.4 ± 0.08 |
| CD34+CD133+, % live cells | 0.2 ± 0.03 | 0.19 ± 0.03 | 0.18 ± 0.03 | 0.21 ± 0.05 | 0.21 ± 0.04 | 0.19 ± 0.03 |
Values are expressed as means ± SE.
VEGF, vascular endothelial growth factor; FGF2, fibroblast growth factor 2; G-CSF, granulocyte colony-stimulating factor; CCL2, chemokine (C-C motif) ligand 2; ET-1, endothelin-1.
*
P < 0.05 vs. Control.