Fig. 2.

Model of AKI to chronic kidney disease (AKI-to-CKD). Twenty-eight days following AKI, serum creatinine (Cr), blood urea nitrogen (BUN), urine neutrophil gelatinase-associated lipocalin (NGAL), and serum IL-6 remain elevated (A, B, C, and D). There is no difference in serum IL-10 (E). Lung myeloperoxidase (MPO) is significantly increased (F). There is evidence of renal fibrosis via Pricrosirius Red staining (G) as well as immunohistochemistry staining for collagen type III (H), and in detection of α-smooth muscle actin (SMA) via Western blot (I, J); n = 5, *P < 0.05.