Fig. 8.

Effect of renal medullary interstitial infusions of isosmotic (284 mosmol/kgH₂O), hyperosmotic saline (1,800 mosmol/kgH₂O) with or without the nonselective antagonist of P2 receptors, suramin, on the relative inner medullary mRNA expression of ET-1 in anesthetized male and female rats. Values represent fold change from corresponding isosmotic saline levels. Data are means ± SE of 5–7 samples in each group. *P < 0.05 vs. corresponding isosmotic saline values. †P < 0.05 vs. corresponding hyperosmotic saline values.