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Inhibitory Effects of NE are mediated by β-ARs and replicated by cAMP. Microglia were incubated with LPS (1 ng/ml) and indicated concentrations of (A) isoproterenol or (B) dibutyryl-cyclic AMP (dbcAMP). Nitrite levels were measured after 24 hours. ***, P < 0.001 versus LPS alone.