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Protein Kinase A does not mediate Effects of NE. Microglia were incubated with LPS (1 ng/ml) alone or with NE (1 μM), and in the presence of (A) the selective PKA inhibitor KT5720; or (B) the PKA and PKC inhibitor H89. Nitrite levels were measured after 24 hr. ***, P < 0.001 versus LPS alone; §§§, P < 0.001 versus LPS plus NE.
