TABLE 7.

Publications on C. albicans describing attenuated virulence related to specific gene disruptions

Gene	Function	Locus containing URA3a	Reference(s)
AAF1	Unknown function	AAF1	66
ADE2	Phosphoribosylaminoimidazole carboxylase	ADE2	27
ALO1	d-Arabinono-1,4-lactone oxidase	ALO1	36
ALS1	Surface adhesin	ALS1	29
ASH1	Transcription factor	ASH1	39
BGL2	(1-3) β-Glucosyltransferase	BGL2	71
CAP1	Adenyl cyclase regulator	eno::URA3	4, 5
CAT1	Catalase	CAT1	91
CDC10	Septin	ARG4	88
CDC11	Septin	ARG4	88
CDC24	GDP:GTP exchange factor	RPS10	8
CDC35	Adenyl cyclase regulator	part of plasmid pVEC	67
CDC42	G protein (GTPase)	RPS10	8
CHS1	Chitin synthase	CHS1 under mal promoter	58
CHS3	Chitin synthase	CHS3	14, 58
CLA4	Ser/Thr protein kinase	CLA4	50
CNA	Calcineurin A	CNA	70
CNB1	Calcineurin B	CNB1	11
COS1	Histidine kinase	COS1?	75
CPP1	Protein phosphatase	CPP1	20
CRK1	Cdc2 kinase	CRK1	18
CSP37	37-kDa surface protein	CSP37	76
CST20	MEKK kinase	CST20	49
EFG1	Transcription factor	EFG1	52
FAS2	Fatty acid synthase	FAS2	98
FTR1	High-affinity iron permease	FTR1	64
GNA1	Glucosamine-6-phosphate acetyltransferase	GNA1	56
GP17	Transcription factor	GP17	65
HEM3	Uroporphyrin I synthase	URA3	44
HK1	Histidine kinase	HK1	17, 93
HOG1	Mitogen-activated protein kinase	MKC1	2
HWP1	Transglutaminase	HWP1, ENO1	21, 80, 82, 85
ICL1	Isocitrate lyase	ICL1	53
INT1	Surface protein	INT1	10, 30
KEX2	Kexin (subtilase)	KEX2	62
LIG4	DNA ligase	LIG4	3
MAD2	Spindle assembly factor	MAD2	6
MDR1	Membrane efflux pump	MDR1	9
MKC1	Mitogen-activated protein kinase	MKC1	26
MNT1	α-1,2-Mannosyl transferase	MNT1	15
NAG1	N-Acetylglucosamine-6-phosphate deaminase	NAG1	77, 94
NAG2	N-Acetylglucosamine phosphate deacetylase	NAG2	94
NAG6	N-Acetylglucosamine kinase	NAG6	94
NIK1	Histidine kinase	NIK1	93
NMT1	N-Myristoyl transferase	NMT1	89
NRG1	Transcriptional repressor	NRG1	60
PHR1	pH-regulated expression	PHR1	24, 32
PLB1	Phospholipase B	PLB1	51, 57
PMT1	Protein O mannosylation	PMT1	83
RAS1	Regulates gene expression	Part of plasmid pVEC	49
RBT1	Hypha-specific wall protein	RBT1	12
RBT4	Unknown function	RBT4	12
RFG1	Transcription factor	RFG1	42
RIM101	Transcription factor	NotI-digested pRS-ARG-URA-BN	23
RIM8	Transcription factor	NotI-digested pRS-ARG-URA-BN	23
RSR1	GTPase	RSR1	92
SAP1	Aspartyl proteinase	SAP1	35
SAP2	Aspartyl proteinase	SAP2	35
SAP3	Aspartyl proteinase	SAP3	35
SAP4-6	Aspartyl proteinases	SAP5	69
SLN1	Histidine kinase	SLN1	93
SOD1	Cu/Zn superoxide dismutase	SOD1	38
SPT3	Transcriptional activator	SPT3	47
SSK1	Two-component response regulator	SSK1	16
SSN6	Transcriptional corepressor	SSN6	37
TEC1	Hyphal transcription factor	Part of plasmid pVEC	74
TOP1	Topoisomerase	Upstream of TOP1, part of inducible promoter construct	41
TPK2	Protein kinase A subunit	TPK2	79
TPS1	Trehalose phosphate synthase	TPS1	97
TPS2	Trehalose phosphate phosphatase	TPS2	86
TUP1	Transcription regulator	TUP1	60
URA3	Nucleotide synthesis		44
VPS34	Phosphoinositol-3-kinase	VPS34	13

^aThe URA3 position in the mutants is indicated according to the information published.