Table 4. Comparisons of peak neutralizing and binding antibody response rates by treatment group (Fisher's exact test).*.
| Virus or Antigen | Vaccine regimen P‐value | |||||
|---|---|---|---|---|---|---|
| M/M/P/P | M/M/P/P | M/M/P/P | MP/MP | MP/MP | D/D/M/M | |
| MP/MP | D/D/M/M | D/D/MP/MP | D/D/M/M | D/D/MP/MP | D/D/MP/MP | |
| (T1 vs T2) | (T1 vs T3) | (T1 vs T4) | (T2 vs T3) | (T2 vs T4) | (T3 vs T4) | |
| Neutralizing | ||||||
| Tier 1 (Clade C) | ||||||
| MW965.26 | 0.40 | <0.001 | 0.12 | <0.001 | 0.49 | <0.001 |
| Tier 1 (Clade B) | ||||||
| MN.3 | <0.001 | <0.001 | 0.0004 | 0.01 | 0.79 | 0.003 |
| SF162.LS | 0.002 | <0.001 | 0.21 | 0.33 | 0.33 | 0.02 |
| Tier 2 (Clade C) | ||||||
| Du151.2 | 1.00 | NA | 1.00 | 1.00 | 1.00 | 1.00 |
| TV1.21 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
| Binding | ||||||
| 1086 gp120) (C) | 1.00 | <0.001 | 0.05 | <0.001 | 0.16 | <0.001 |
| Con 6 gp120/BC | 1.00 | <0.001 | 0.05 | <0.001 | 0.16 | <0.001 |
| Con S gp140 CFI | 1.00 | <0.001 | 0.25 | <0.001 | 0.25 | 0.01 |
| o‐gpTV1ΔV2 © | 1.00 | <0.001 | 0.60 | <0.001 | 1.00 | <0.001 |
*2-sided P-values are Holm-Bonferroni adjusted (across the 6 pairs of treatment arm comparisons) for each antigen. M/M/P/P: MVA prime, sequential gp140 boost; MP/MP: concurrent MVA/gp140; D/D/M/M: DNA prime, sequential MVA boost; D/D/MP/MP: DNA prime, concurrent MVA/gp140 boost).