FIG. 7.
Cercosporamide and a β-1,3-glucan synthase inhibitor, an echinocandin analog, together have markedly enhanced antifungal activity. (A) MICs of cercosporamide (Cercos), echinocandin analog (ECB), and amphotericin B (amphoB) against C. albicans. (B) Dramatically increased antifungal activity of cercosporamide, seen as a marked decrease in its MIC in the presence of ECB at an ECB concentration that by itself has no apparent antifungal activity.