Fig 7. D-criterion and E-criterion for different experimental designs for the Immigration-Death model for all three methods (MSS, benchmark and exact).

FI_⋅ Fisher information and FI_emp,⋅ are calculated for different inter-sample distances. The solid line is an interpolation of the values of FI_⋅ and the “x” denote the values of FI_emp,⋅. Red color corresponds to the MSS method, blue to the benchmark and black to the exact method. Symbols partially overlapping.