Table 2.

Brain clusters showing significant effect of diagnosis on centrality

			MNI			Diagnosis*		SZ–control		BD–control		SZ–BD
Cluster	Anatomic region	Voxels	x	y	z	F (η2p)	p value	t†	p value	t†	p value	t†	p value
rdlFL	r dl frontal lobe	642	28	76	54	24.18 (0.137)	< 0.001	6.91	< 0.001	2.39	0.017	2.89	0.004
ldlFL	l dl frontal lobe	63	70	72	56	11.68 (0.071)	< 0.001	4.80	< 0.001	1.53	0.13	2.13	0.034
dmFL	dm frontal lobe	1100	50	83	54	14.53 (0.087)	< 0.001	5.35	< 0.001	1.79	0.07	2.29	0.023
rpPL	r p parietal/angular gyrus	1770	21	34	49	26.45 (0.148)	< 0.001	7.27	< 0.001	1.48	0.14	3.94	< 0.001
lpPL	l p parietal/angular gyrus	140	74	32	55	13.49 (0.081)	< 0.001	4.72	< 0.001	3.13	0.002	0.69	0.49
rOC	r occipital cortex	381	23	37	28	21.23 (0.122)	< 0.001	−6.25	< 0.001	0.49	0.62	−4.91	< 0.001
lOC	l occipital cortex	2014	63	26	40	25.74 (0.144)	< 0.001	−7.16	< 0.001	−1.01	0.32	−4.27	< 0.001
SS	somatosensory	1719	42	41	74	19.90 (0.115)	< 0.001	−5.50	< 0.001	1.87	0.06	−5.56	< 0.001
rHPC	r hippocampus/amygdala	838	31	63	29	31.16 (0.170)	< 0.001	−7.50	< 0.001	−4.00	< 0.001	−1.93	0.06
lHPC	l hippocampus/amygdala	750	55	48	33	26.51 (0.148)	< 0.001	−7.03	< 0.001	−3.36	0.001	−2.14	0.033
rPUT	r putamen	399	29	55	39	14.45 (0.087)	< 0.001	−3.90	< 0.001	−4.44	< 0.001	1.04	0.30
lPUT	l putamen	628	60	53	38	15.50 (0.092)	< 0.001	−4.34	< 0.001	−4.27	< 0.001	0.530	0.59

ANCOVA = analysis of covariance; BD = bipolar disorder; dl = dorsolateral; dm = dorsomedial; FL = frontal lobe; HPC = hippocampus; l = left; MNI = Montreal Neurological Institute; OC = occipital cortex; p = posterior; PL = parietal lobe; PUT = putamen; r = right; SS = somatosensory; SZ = schizophrenia.

^*An ANCOVA F-test was run for effect of diagnosis in each cluster, with 2 degrees of freedom, with pairwise comparisons distinguishing among the 3 groups.

^†Positive t values show an increase in patients with schizophrenia and BD compared with healthy controls, and in patients with schizophrenia compared with patients with BD.