Table 2.

PICU and hospital length of stay, illness severity, organ dysfunction, and mortality outcomes in sepsis protocol patients vs non-protocol (usual care) patients.

	Sepsis Protocol		Odds Ratio (95% CI)	p
	Yes (n=121)	No (n=68)
Length of Stay (Median hours, IQR)
PICU LOS	69.0 (35.8–120.9)	196.5 (100.5–339.7)		<0.001
Hospital LOS	140.0 (93.5–237.6)	347.7 (211.8–557.9)		<0.001
Illness severity score on PICU arrival (Median, IQR)
PIM2	1.1 (1.0, 2.1))	3.6 (1.0, 4.9)		0.14
PRISM	3 (0,10)	6 (3, 10)		0.10
PICU Care Requirements
Ever needed vasoactive support n(%)	48 (39.6)	18 (26.9)	1.4 (0.9, 2.3)	0.10
Ever needed invasive mechanical ventilation	8 (6.6)	11 (16.4)	0.4 (0.2, 0.9)	0.03
Ever needed PRBC transfusion	8 (6.6)	2 (3.0)	2.2 (0.5, 10.1)	0.3
Bacterial organism isolated	42 (34.7)	24 (35.8)	0.9 (0.6, 1.4)	0.7
Transfer to higher level of care n (%)
Floor to PICU transfer <24h	10 (8.2)	18 (26.9)	0.3 (0.2, 0.6)	0.006
Organ Dysfunction
Organ dysfunction free on hospital admission	18 (14.9)	11 (16.4)	0.9 (0.4, 2.0)	0.80
Organ dysfunction free D1	49 (40.5)	9 (13.4)	4.4 (2.0, 9.7)	<0.001
Organ dysfunction free D2	61 (50.4)	11 (16.4)	5.2 (2.5, 10.8)	<0.001
Developed new organ dysfunction on D1 or D2	5 (4.1)	11 (16.4)	0.3 (0.1, 0.7)	0.004
Mortality
In hospital mortality	4 (3.3)	2 (2.9)	1.1 (0.2, 5.9)	0.9