Table 5.

Top ten associations in random effects meta-analyses of weight loss

Chr	Gene	SNP	Minor allele	MAF	Fixed effect (N=334)				Random effect (N=334)				Carress (N=38)				Dose (N=55)				Rose (N=241)
					P value	$\widehat{\beta }\text{genetic}$	Lower CL	Upper CL	P value	$\widehat{\beta }\text{genetic}$	Lower CL	Upper CL	P value	$\widehat{\beta }\text{genetic}$	Lower CL	Upper CL	P value	$\widehat{\beta }\text{genetic}$	Lower CL	Upper CL	P value	$\widehat{\beta }\text{genetic}$	Lower CL	Upper CL
13	ABCC4	rs17268282	A	0.059	0.0001	−2.48	−3.68	−1.27	0.0001	−2.48	−3.68	−1.27	0.7051	−0.81	−5.15	3.53	0.9019	−0.32	−5.58	4.93	3.99E-05	−2.78	−4.09	−1.47
13	ABCC4	rs1751003	A	0.159	0.0004	1.37	0.62	2.13	0.0004	1.37	0.62	2.13	0.3778	1.72	−2.22	5.67	0.2438	1.30	−0.92	3.52	0.0013	1.37	0.54	2.20
13	ABCC4(dist=82196). CLDN10(dist=49970)	rs7982352	G	0.138	0.0004	−1.49	−2.31	−0.67	0.0004	−1.49	−2.31	−0.67	0.2050	−2.35	−6.06	1.37	0.4124	−0.97	−3.35	1.40	0.0013	−1.51	−2.43	−0.60
13	ABCC4	rs16950829	G	0.021	0.0007	−3.35	−5.27	−1.42	0.0007	−3.35	−5.27	−1.42	0.9458	0.30	−8.69	9.29					0.0005	−3.54	−5.53	−1.55
13	ABCC4	rs148748821	A	0.150	0.0009	1.33	0.54	2.11	0.0009	1.33	0.54	2.11	0.6820	0.94	−3.72	5.60	0.2438	1.30	−0.92	3.52	0.0024	1.35	0.48	2.21
13	ABCC4	rs2148529	C	0.115	0.0035	1.28	0.42	2.15	0.0035	1.28	0.42	2.15	0.8538	0.60	−6.03	7.24	0.2589	1.24	−0.95	3.43	0.0077	1.31	0.35	2.27
12	SCNN1A	rs3782721	A	0.132	0.0040	1.21	0.38	2.03	0.004	1.21	0.38	2.03	0.7319	0.70	−3.43	4.82	0.6162	0.68	−2.03	3.39	0.0047	1.29	0.40	2.19
13	ABCC4	rs4771912	G	0.124	0.0049	−1.18	−2.00	−0.36	0.0049	−1.18	−2.00	−0.36	0.6801	−0.91	−5.37	3.56	0.9349	−0.09	−2.22	2.05	0.0029	−1.40	−2.32	−0.48
13	ABCC4(dist=102109). CLDN10(dist=30057)	rs17235229	G	0.136	0.0050	1.13	0.34	1.91	0.005	1.13	0.34	1.91	0.3751	2.08	−2.65	6.81	0.3131	0.96	−0.94	2.86	0.0132	1.13	0.24	2.02
13	ABCC4	rs9516530	A	0.411	0.0055	0.83	0.24	1.42	0.0055	0.83	0.24	1.42	0.9734	0.05	−2.86	2.96	0.1053	1.30	−0.28	2.88	0.0185	0.79	0.13	1.45

Chr, Chromosome; CL: confidence limit; MAF, minor allele frequency; SNP, single nucleotide polymorphism. All analyses were adjusted for age, sex, the first four principal components of population structure, furosemide intravenous dose equivalent received from baseline to 72 hours, body mass index at baseline, baseline estimated glomerular filtration rate and randomization group.