Table 2. Overview on patient population.

Patient number	Onset			CI	PPD (months)	Clinical features (weakness and atrophy)			Absent TR	Tremors
	Age (years)	Side	SS			Hands intrinsics MM	Fingers extensors MM	Biceps/triceps brachii MM
1	19	Bilateral	Tremor and hand weakness	Yes (L > R)	12	No	Yes (L>R)	No	Distal reflexes at upper limbs	Yes (bilateral)
2	15	Bilateral	Tremor and hand weakness	Yes (R > L)	36	Yes (R > L)	Yes (R > L)	No	Distal reflexes at upper limbs	Yes (R hand)
3	17	R	Progressive hand weakness	Yes	36	Yes (R > L)	Yes (R > L)	Yes (tricipital)	Distal reflexes at upper limbs and R tricipital	No
4	18	R	Hyperhidrosis and hand weakness	Yes	12	No	Yes (R > L)	No	Distal reflexes at upper limbs	No
5	17	R	Progressive hand weakness	Yes	12	Yes	Yes	No	Distal reflexes at upper limbs	No
6	23	L	Tremor and hand weakness	Yes	36	Yes	Yes	No	Distal reflexes at upper limbs	Yes (L > R)
7	16	L	Hyperhidrosis and hand weakness	Yes	24	Yes	Yes	No	Distal reflexes at upper limbs	No
8	18	L	Progressive weakness	Yes	8	Yes	Yes	No	Distal reflexes at upper limbs	No

SS, signs and symptoms; CI, contralateral involvement; PPD, progression phase duration; MM, muscles; TR, tendon reflexes, L, left; R, right.