Table 1.
Properties of evoked unitary EPSCs in nRt cells
| Type 1 | Type 2 | P Value | |
|---|---|---|---|
| Latency, ms** | 1.69 ± 0.08 (n = 64) | 2.07 ± 0.12 (n = 29) | 0.00970 |
| Propagation speed, mm/ms* | 0.41 ± 0.02 (n = 63) | 0.32 ± 0.02 (n = 27) | 0.01210 |
| EPSC amplitude, pA* | 473 ± 48 (n = 64) | 307 ± 48 (n = 29) | 0.03538 |
| EPSC 10–90% rise time, ms*** | 0.35 ± 0.01 (n = 64) | 0.50 ± 0.03 (n = 29) | 0.00000 |
| EPSC half-width, ms*** | 1.14 ± 0.05 (n = 64) | 1.99 ± 0.11 (n = 29) | 0.00000 |
| EPSC Aslow, pA | 30 ± 3 (n = 64) | 37 ± 6 (n = 29) | 0.25652 |
| EPSC Afast, pA* | 409 ± 41 (n = 64) | 254 ± 41 (n = 29) | 0.02415 |
| EPSC %slow*** | 7.5 ± 0.3 (n = 64) | 14.5 ± 1.3 (n = 29) | 0.00000 |
| EPSC τslow, ms*** | 16.36 ± 0.80 (n = 64) | 25.09 ± 2.25 (n = 29) | 0.00002 |
| EPSC τfast, ms*** | 0.97 ± 0.05 (n = 64) | 1.72 ± 0.11 (n = 29) | 0.00000 |
| EPSC τD,W, ms*** | 2.07 ± 0.09 (n = 64) | 4.65 ± 0.25 (n = 29) | 0.00000 |
All data are means ± SE. Control conditions with a single excitatory postsynaptic current (EPSC) at −70 mV are shown. Responses were obtained under conditions isolating ionotropic glutamate EPSCs composed of both non-N-methyl-d-aspartate (NMDA)- and NMDA-dependent responses. nRt, thalamic reticular nucleus; Afast and Aslow, fast and slow amplitude components, respectively; %slow, percentage of the slow component; τfast and τslow, fast and slow decay time constants, respectively; τD,W, weighted decay time constant. Statistical significance was calculated using an independent Student's t-test.
*
P < 0.05;
**
P < 0.01;
***
P < 0.001.