Fig. 2.

Ectopic bone formation: (a) One representative construct at T0 is shown: β-TCP-granules (Δ) are clearly seen forming a solid construct. (b) The same construct at time point T1; pores (*) and the spaces between the granules and the periphery of the construct (→) are filled with bone. Even though some “big pores” are not completely filled with bone over time, a smaller pore (+) remains in T1 compared to T0. The construct became compact and dense over time. (c) Histomorphometry shows a dense construct, bone was detectable (*). (d) A mCT-scout scan showing the implants within the animal.