FIGURE 8.

Alterations in LH receptor, steroidogenic acute regulatory protein, 20α-hydroxysteroid dehydrogenase, activin, and inhibin mRNA levels in the testes of Mrc1^−/−, Asgr2^−/−, and Mrc1^−/−Asgr2^−/− mice. Testes were collected from adult male WT (n = 4), Mrc1^−/− (n = 4), Asgr2^−/− (n = 4), and Mrc1^−/−Asgr2^−/− (n = 4) mice, and the relative quantity of mRNA was determined by PCR. mRNA levels differed from those of WT mice as follows. Panel A, LH receptor (LHR) in Mrc1^−/−Asgr2^−/− (p = 0.005) mice but not in Mrc1^−/− or Asgr2^−/− mice. Panel B, StAR in Mrc1^−/−Asgr2^−/− (p = 0.0002) mice but not in Mrc1^−/− or Asgr2^−/− mice. Panel C, 20αHSD in Mrc1^−/− (p = 0.001) and Mrc1^−/−Asgr2^−/− (p = 0.0001) mice but not Asgr2^−/− mice. Panel D, activin in Mrc1^−/−Asgr2^−/− (p = 0.002) mice but not in either Mrc1^−/− or Asgr2^−/− mice. Panel E, inhibin in Mrc1^−/− (p = 0.05) and Mrc1^−/−Asgr2^−/− (p = 0.0008) mice but not Asgr2^−/− mice.