FIGURE 4.

Variations in Ly49 configuration. A, the configuration of the Ly49 homo-dimer from the following structures is shown in ribbon representation with the α-helices in red and in two different orientations: Ly49C·H2-Q10 (left), Ly49C·H-2K^b (middle), and Ly49A·H2-D^d (right). B, overlay of the Ly49C homo-dimer in the H2-Q10 bound (magenta) and H2-K^b bound (gray) states showing the relative difference in domain juxtapositioning. The molecules were aligned based on the left-hand side monomer. C, the same structural alignment as described in B, but in this case, only the MHC-I are shown. The peptides are shown as sticks in green (Ly49C·H2-Q10) or black (Ly49C·H-2K^b).