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Model of FOXO's contribution to maintaining proteostasis by controlling expression of both families of Hsp chaperones. Acute oxidative stress activates FOXO, and dFOXO directly transcriptionally up-regulates the sHsps and Hsp70 genes. The two families of chaperones protect against proteotoxicity using separate mechanisms. The role for dFOXO in transcriptional regulation of HSF has not been fully elucidated.
