Table 2.

Clinical studies based on Implantable Loop Recorder findings.

Trial	Inclusion criteria	No therapy or pacemaker OFF arm				Pacemaker ON arm				Analysis
		N	Female (%)	Mean age (years)	Recurrence of syncope	N	Female (%)	Mean age	Recurrence of syncope
ISSUE 2	≥ 3 episodes in 2 years	50	50	64	41%	53	62	69	10%	Relative risk reduction 80%, p=0.002
ISSUE 3	≥ 3 episodes in 2 years	39	59	63	57%	38	47	63	25%	57% relative reduction, p=0.039

N: number of patients.