Table 1.
Baseline Characteristics According to the Presence of Granulomatosis with Polyangiitis
| Variables | Granulomatosis with Polyangiitis (n=465) |
Comparison Cohort (n=4613) |
P | |
|---|---|---|---|---|
| Age, years | 60.3 ± 14.6 | 60.3 ± 14.6 | 0.95 | |
| Sex | ||||
| Male | 245 (52.7%) | 2419 (52.4%) | 0.92 | |
| Female | 220 (47.3%) | 2194 (47.6%) | ||
| BMI (kg/m2) | 0.76 | |||
| Mean ± SD | 26.8 ± 5.1 | 26.9 ± 5.2 | ||
| <18.5 | 13 (2.8%) | 59 (1.3%) | ||
| 18.5–24.9 | 132 (28.4%) | 1390 (30.1%) | ||
| 25.0–29.9 | 145 (31.2%) | 1435 (31.1%) | ||
| ≥30.0 | 86 (18.5%) | 828 (17.9%) | ||
| Unknown | 89 (19.1%) | 901 (19.5%) | ||
|
Socio-Economic Deprivation Index Score |
2.6 ± 1.4 | 2.6 ± 1.4 | 0.78 | |
| Smoking | 0.01 | |||
| None | 229 (49.2%) | 2310 (50.1%) | ||
| Past | 128 (27.5%) | 993 (21.5%) | ||
| Current | 70 (15.1%) | 830 (18.0%) | ||
| Unknown | 38 (8.2%) | 480 (10.4%) | ||
| Alcohol | 0.58 | |||
| None | 72 (15.5%) | 663 (14.4%) | ||
| Past | 10 (2.2%) | 67 (1.5%) | ||
| Current | 298 (64.1%) | 2993 (64.9%) | ||
| Unknown | 85 (18.3%) | 890 (19.3%) | ||
| Charlson Comorbidity Index | 0.7 ± 1.2 | 0.3 ± 0.9 | <0.001 | |
| GP Visits | 6.1 ± 4.3 | 3.0 ± 3.5 | <0.001 | |
| Hypertension | 144 (31.0%) | 1303 (28.2%) | 0.22 | |
| Hyperlipidemia | 95 (20.4%) | 898 (19.5%) | 0.62 | |
| Stroke | 30 (6.5%) | 196 (4.2%) | 0.03 | |
| Ischemic Heart Disease | 45 (9.7%) | 403 (8.7%) | 0.50 | |
| Chronic Kidney Disease | 63 (13.5%) | 185 (4.0%) | <0.001 | |
| Diabetes | 24 (5.2%) | 326 (7.1%) | 0.12 | |
|
Angiotensin Converting Enzyme Inhibitor |
69 (14.8%) | 630 (13.7%) | 0.48 | |
| Aspirin | 74 (15.9%) | 627 (13.6%) | 0.17 | |
|
Angiotensin II Receptor Blockers |
21 (4.5%) | 218 (4.7%) | 0.84 | |
| Beta-Blockers | 69 (14.8%) | 599 (13.0%) | 0.26 | |
| Calcium Channel Blockers | 82 (17.6%) | 545 (11.8%) | <0.001 | |
| Diuretics | 111 (23.9%) | 714 (15.5%) | <0.001 | |
| NSAIDs | 160 (34.4%) | 846 (18.3%) | <0.001 | |
| Glucocorticoids | 182 (39.1%) | 203 (4.4%) | <0.001 | |
| Albumin, mmol/L | 37.0 ± 6.3 | 42.3 ± 3.7 | <.0001 | |
| Cholesterol, mmol/L | 5.0 ± 1.3 | 5.2 ± 1.1 | 0.03 | |
Data are represented as mean ± standard deviation (SD) or number (percentage); Socio-Economic Deprivation Index score was measured by the Townsend Deprivation Index, which was grouped into quintiles from 1 (least deprived) to 5 (most deprived); Hyperlipidemia is defined as having either a diagnosis of hyperlipidemia or a prescription for antihyperlipidemics; Glucocorticoids are oral or injectable steroids; Diuretics are loop or thiazide diuretics.