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. Author manuscript; available in PMC: 2017 Feb 1.
Published in final edited form as: Semin Arthritis Rheum. 2015 Aug 3;45(4):483–489. doi: 10.1016/j.semarthrit.2015.07.009

Table 2.

Incidence Rates and Hazard Ratios (HR) for Associations Between Granulomatosis with Polyangiitis (GPA) and Death (1992–2013)

GPA
Status		 N Deaths Follow-
up
Time
(person-
years)		 Mean
Follow-
up
(years)		 Incidence
Rate (cases
per 1000
person-
years)		 Age, Sex,
and
Entry-
time
Matched
HR
(95%CI)* 		+ GPs visits,
BMI, SDI,
Smoking,
Alcohol, and
Charlson Index
Adjusted HR
(95%CI)		 +
Comorbidity
and
Medicines
Adjusted
HR*
(95%CI)
Total Yes 465 101 2321.5 5.0 43.51 (35.44
to 52.86)		 2.76 (2.19
to 3.47)		 2.64 (2.07 to
3.38)		 2.52 (1.91 to
3.32)
No 4613 511 26521.4 5.7 19.27 (17.63
to 21.01)		 1.0
(reference)		 1.0 (reference) 1.0
(reference)
Female Yes 220 38 1182.7 5.4 32.13 (22.74
to 44.10)		 2.20 (1.54
to 3.16)		 2.31 (1.57 to
3.39)		 2.22 (1.45 to
3.38)
No 2194 235 13097.2 6.0 17.94 (15.72
to 20.39)		 1.0
(reference)		 1.0 (reference) 1.0
(reference)
Male Yes 245 63 1138.9 4.6 55.32 (42.51
to 70.77)		 3.27 (2.42
to 4.41)		 2.86 (2.06 to
3.96)		 2.87 (1.96 to
4.20)
No 2419 276 13424.2 5.5 20.56 (18.21
to 23.13)		 1.0
(reference)		 1.0 (reference) 1.0
(reference)
Age ≤
65 		Yes 275 32 1603.7 5.8 19.95 (13.65
to 28.17)		 3.13 (2.07
to 4.72)		 2.75 (1.76 to
4.30)		 2.52 (1.51 to
4.19)
No 2730 116 16683.1 6.1 6.95 (5.75 to
8.34)		 1.0
(reference)		 1.0 (reference) 1.0
(reference)
Age >
65 		Yes 190 69 717.9 3.8 96.11 (74.78
to 121.64)		 2.61 (1.98
to 3.44)		 2.57 (1.91 to
3.46)		 2.37 (1.69 to
3.34)
No 1883 395 9838.3 5.2 40.15 (36.29
to 44.31)		 1.0
(reference)		 1.0 (reference) 1.0
(reference)
*

Adjusted for all of the covariates in Table 1