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. Author manuscript; available in PMC: 2017 Feb 1.
Published in final edited form as: Semin Arthritis Rheum. 2015 Aug 3;45(4):483–489. doi: 10.1016/j.semarthrit.2015.07.009

Table 3.

Incidence Rates and Hazard Ratios (HR) for Associations Between Granulomatosis with Polyangiitis (GPA) and Death According to Different Follow Up Time Period

GPA
Status		 N Deaths Follow-
up
Time
(person-
years)		 Mean
Follow-
up
(years)		 Incidence
Rate (cases
per 1000
person-
years)		 Age, Sex,
and Entry-
time
Matched
HR
(95%CI)* 		+ GPs visits,
BMI, SDI,
Smoking,
Alcohol, and
Charlson
Index
Adjusted HR
(95%CI)		 +
Comorbidity
and
Medicines
Adjusted
HR*
(95%CI)
Overall Yes 465 101 2321.5 5.0 43.51 (35.44
to 52.86)		 2.76 (2.19
to 3.47)		 2.64 (2.07 to
3.38)		 2.52 (1.91 to
3.32)
No 4613 511 26521.4 5.7 19.27 (17.63
to 21.01)		 1.0
(reference)		 1.0 (reference) 1.0
(reference)
0–1
year 		Yes 465 40 410.7 0.9 97.39 (69.58
to 132.62)		 6.67 (4.44
to 10.00)		 6.85 (4.21 to
11.15)		 6.31 (3.62 to
10.98)
No 4613 62 4344.8 0.9 14.27 (10.94
to 18.29)		 1.0
(reference)		 1.0 (reference) 1.0
(reference)
0–3
years 		Yes 465 61 1050.8 2.3 58.05 (44.40
to 74.57)		 3.66 (2.72
to 4.94)		 3.54 (2.56 to
4.90)		 3.35 (2.31 to
4.85)
No 4613 196 11477.0 2.5 17.08 (14.77
to 19.64)		 1.0
(reference)		 1.0 (reference) 1.0
(reference)
0–5
years 		Yes 465 72 1531.2 3.3 47.02 (36.79
to 59.22)		 3.03 (2.32
to 3.97)		 2.94 (2.21 to
3.92)		 2.78 (2.01 to
3.84)
No 4613 290 16702.2 3.6 17.36 (15.42
to 19.48)		 1.0
(reference)		 1.0 (reference) 1.0
(reference)
0–10
years 		Yes 465 91 2143.5 4.6 42.45 (34.18
to 52.12)		 2.66 (2.10
to 3.38)		 2.61 (2.02 to
3.37)		 2.51 (1.88 to
3.36)
No 4613 442 23807.0 5.2 18.57 (16.88
to 20.38)		 1.0
(reference)		 1.0 (reference) 1.0
(reference)
*

Adjusted for all of the covariates in Table 1