Table 2. Factors associated with long-term mortality in a Cox regression model* taking into account time-varying covariates.
| Before match* |
p | After match** |
P | |||||
|---|---|---|---|---|---|---|---|---|
| HR | Lower 95% CI | Upper 95% CI | HR | Lower 95% CI | Upper 95% CI | |||
| Age (in year) | 1.05 | 1.04 | 1.06 | <0.001 | 1.05 | 1.03 | 1.06 | <0.001 |
| Male gender | 1.31 | 1.08 | 1.59 | <0.001 | ||||
| Premorbid risk | ||||||||
| CKD | 2.16 | 1.62 | 2.87 | <0.001 | ||||
| Congestive heart failure | 1.90 | 1.47 | 2.46 | <0.001 | ||||
| Liver disease | 1.87 | 1.44 | 2.42 | <0.001 | 2.13 | 1.35 | 3.35 | <0.001 |
| Coronary artery disease | 1.90 | 1.30 | 2.77 | <0.001 | ||||
| Dementia | 1.73 | 1.09 | 2.74 | <0.019 | ||||
| Hemiplegia | 2.68 | 1.68 | 4.28 | <0.001 | 3.77 | 1.81 | 7.89 | <0.001 |
| Diabetes Mellitus | 1.42 | 1.16 | 1.73 | <0.001 | ||||
| Solid tumor | 1.81 | 1.35 | 2.43 | <0.001 | 3.39 | 2.15 | 5.37 | <0.001 |
| Time-varying covariate | ||||||||
| Adrenalectomy | ||||||||
| Residual hypertension+ | 0.28 | 0.18 | 0.44 | <0.001 | 0.23 | 0.13 | 0.26 | <0.001 |
| Resolved hypertension+ | 0.25 | 0.14 | 0.44 | <0.001 | 0.21 | 0.10 | 0.24 | <0.001 |
| MRA | 1.15 | 0.91 | 1.45 | 0.237 | 1.53 | 0.19 | 2.59 | 0.110 |
| K supply | 1.94 | 1.47 | 2.56 | <0.001 | 1.64 | 1.06 | 2.55 | 0.028 |
Abbreviations: CI, confidence interval; CKD, chronic kidney disease; COPD, chronic obstructive pulmonary disease; HR, hazard ratio; K, potassium; MRA, mineralocorticoid receptor antagonist.
*The final model had a good validity (C-index = 0.83).
**The final model had a good validity (C-index = 0.79).
+Cure of hypertension is defined as no use of antihypertensive drug for at least 1 year after adrenalectomy.