Figure 5.
Schematic representation of the proposed mechanism for the intestinal lymphatic transport of Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD) following oral co-administration with dietary fats of long-chain triglycerides (LCT). (1) Intestinal solubilisation of THC and CBD in the mixed micelles as a result of lipid digestion process. (2) Uptake of cannabinoids by the chylomicrons (CM) inside the enterocytes. (3) Transfer of THC and CBD by CM to the systemic circulation via the intestinal lymphatic system avoiding hepatic first-pass metabolism.