Table 2.
Phenotypic variation of selected parameters in inbred and outbred mice before and after subcutaneous dosing with human insulin
| BALB/c (n=48) | C57BL/6 (n=48) | NMRI (n=49) | CD-1 (n=50) | |||||
|---|---|---|---|---|---|---|---|---|
|
|
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| Mean ± SD | CV (%) | Mean ± SD | CV (%) | Mean ± SD | CV (%) | Mean ± SD | CV (%) | |
| Baseline blood glucose (mM) | 9.0±1.0†† | 10.8 [9.0; 13.5] | 8.5±0.7† | 8.6 [7.2; 10.8] | 8.9±0.9††,† | 10.2 [8.5; 12.8] | 8.7±0. 9††,† | 9.5 [8.0; 11.9%] |
| AOCglucose0-40 (mM×min) | 85.5±22.4†† | 27.8 [23.2; 34.8]a | 114.0±19.3† | 17.0 [14.2; 21.3]b | 94.3±23.5†† | 25.9 [21.6; 32.3]a | 89.2±24.3†† | 24.7 [20.7; 30.8]a |
| Maximal blood glucose effect of HI (mM) | 5.6±0.9††† | 16.4 [13.7; 20.6]d | 4.2±0.5† | 11.0 [9.1; 13.7]c | 4.9±1.0†† | 20.8 [17.4; 26.0]d | 4.8±0.8†† | 17.3 [14.5; 21.6]d |
Numbers given in percentage are coefficients of variations. Brackets designate 95% confidence intervals for coefficients of variation. Superscripts indicate significant (P<0.05) differences in CVs (a,b,c,d) and effect (†, ††, †††) between strains. CV=Coefficient of variation, AOC=Area over the Δblood glucose vs. time curve.