Table 3.
Selected metabolic parameters after 6 weeks exposure to an energy-dense diet (WD) compared with age-matched controls fed standard rodent chow (RC)
| Strain/Stock | Diet | Bodyweight change (g) | Fat mass (g) | Lean mass (g) | Liver weight (g) | Epididymal fat depot (g) |
|---|---|---|---|---|---|---|
| BALB/c | WD | 6.0±1.4*** | 2.5±1.1** | 23.2±1.9 | 2.0±0.3** | 0.6±0.1*** |
| RC | 7.4±1.0 | 1.7±0.5 | 23.5±1.5 | 1.8±0.2 | 0.4±0.1 | |
| C57BL/6 | WD | 12.3±2.7**** | 5.1±2.5**** | 24.8±2.3 | 1.6±0.2* | 1.2±0.5**** |
| RC | 8.1±2.1 | 1.3±0.8 | 24.5±3.1 | 1.4±0.2 | 0.3±0.1 | |
| NMRI | WD | 7.7±4.5 | 5.0±3.7* | 30.6±2.3 | 2.0±0.3** | 1.4±0.9** |
| RC | 6.2±2.2 | 2.6±1.4 | 30.5±1.6 | 1.7±0.03 | 0.7±0.2 | |
| CD-1 | WD | 9.4±4.0* | 5.8±3.6*** | 29.7±2.2** | 2.0±0.3 | 1.6±0.9*** |
| RC | 7.4±1.5 | 2.3±1.0 | 31.5±1.7 | 1.9±0.2 | 0.7±0.2 |
RC=Rodent Chow, WD=Western Diet.
*
indicates p<0.05;
**
indicates p<0.01;
***
indicates p<0.001;
****
indicates p<0.0001.
Comparisons are between WD groups and RC groups within each strain. WD groups: (BALB/c: n=40; C57BL/6: n=39; NMRI: n=40; CD-1: n=40); RC groups: (BALB/c: n=15; C57BL/6: n=15; NMRI: n=14; CD-1: n=15).