Table 4.
Phenotypic variation of selected metabolic parameters in inbred and outbred mice after 6 weeks exposure to an energy-dense diet (Western Diet)
| BALB/c (n=40) | C57BL/6 (n=39) | NMRI (n=40) | CD-1 (n=40) | |||||
|---|---|---|---|---|---|---|---|---|
|
|
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| Mean ± SD | CV (%) | Mean ± SD | CV (%) | Mean ± SD | CV (%) | Mean ± SD | CV (%) | |
| Bodyweight change (g) | 6.0±1.4† | 25.8 [21.1; 33.1]a | 12.3±2.7†† | 22.9 [18.7; 29.4]a | 7.7±4.5†,††† | 53.4 [43.7; 68.9]b | 9.4±4.0††† | 43.7 [35.6; 56.5]b |
| Fat mass (EchoMRI) (g) | 2.5±1.1† | 63.1 [51.7; 81.0] | 5.1±2.5†† | 71.0 [58.0; 91.5] | 5.0±3.7†† | 69.0 [56.5; 88.6] | 5.8±3.6†† | 73.0 [59.8; 93.8] |
| Lean mass (EchoMRI) (g) | 23.2±1.9† | 8.3 [6.8; 10.6] | 24.8±2.3†† | 9.7 [7.9; 12.5] | 30.6±2.3††† | 7.9 [6.4; 10.1] | 29.7±2.2††† | 7.4 [6.0; 9.5] |
| Liver weight (g) | 2.0±0.3† | 12.0 [9.9; 15.5] | 1.6±0.2†† | 15.8 [12.9; 20.4] | 2.0±0.3† | 14.8 [12.1; 19.0] | 2.0±0.3† | 13.4 [11.0; 17.2] |
| Epididymal fat weight (g) | 0.6±0.1† | 25.0 [20.5; 32.1]c | 1.2±0.5†† | 46.9 [38.3; 60.4]d | 1.4±0.9†† | 58.4 [47.8; 75.0]d | 1.6±0.9†† | 56.2 [46.1; 72.2]d |
Numbers given in percentage are coefficients of variations. Brackets designate 95% confidence intervals for coefficients of variation. Superscripts indicate significant (P<0.05) differences in CV’s (a,b,c,d) and effect (†, ††, †††) between strains. CV=Coefficient of variation.