Table 1. Differentially expressed proteins associated with reproductive process in rat testis exposed to arsenic.
| Protein ID | Protein name | Gene name | Change | Fold change (Treatment/Control)a |
||
|---|---|---|---|---|---|---|
| 1 mg/L | 5 mg/L | 25 mg/L | ||||
| Q9R1Z0 | Voltage-dependent anion-selective channel protein 3 | Vdac3 | ↓ | 0.92 ± 0.02 | 0.85 ± 0.06 | 0.74 ± 0.15** |
| P27791 | cAMP-dependent protein kinase catalytic subunit alpha | Prkaca | ↓ | 0.73 ± 0.08** | 0.79 ± 0.13* | 0.79 ± 0.09* |
| B4F772 | Heat shock 70 kDa protein 4L | Hspa4l | ↑ | 1.33 ± 0.04** | 1.21 ± 0.07** | 1.27 ± 0.06** |
| D3Z9F9 | Sperm acrosome membrane-associated protein 1 | Spaca1 | ↓ | 0.79 ± 0.02** | 0.81 ± 0.02** | 0.76 ± 0.08* |
| P15205 | Microtubule-associated protein 1B | Map1b | ↓ | 0.66 ± 0.07* | 0.64 ± 0.11** | 0.70 ± 0.47* |
| P36970 | Glutathione peroxidase 4 | Gpx4 | ↑ | 1.03 ± 0.02 | 1.19 ± 0.08* | 1.29 ± 0.07** |
| O88453 | Scaffold attachment factor B1 | Safb1 | ↓ | 0.81 ± 0.09 | 0.72 ± 0.22* | 0.75 ± 0.07* |
| O08629 | Transcription intermediary factor 1-beta | Trim28 | ↓ | 1.04 ± 0.05 | 0.86 ± 0.08** | 0.79 ± 0.01** |
| P02696 | Retinol-binding protein 1 | Rbp1 | ↓ | 0.71 ± 0.12** | 0.67 ± 0.08** | 0.73 ± 0.06* |
| P16232 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Hsd11b1 | ↑ | 1.25 ± 0.04* | 1.42 ± 0.13** | 1.23 ± 0.04* |
| P21708 | Mitogen-activated protein kinase 3 | Mapk3 | ↑ | 0.94 ± 0.01 | 1.28 ± 0.06** | 1.37 ± 0.03** |
| P35571 | Glycerol-3-phosphate dehydrogenase, mitochondrial | Gpd2 | ↓ | 0.75 ± 0.09 | 0.68 ± 0.29* | 0.6 ± 0.21* |
| P47820 | Angiotensin-converting enzyme | Ace | ↓ | 1.08 ± 0.03 | 0.88 ± 0.02** | 0.72 ± 0.05** |
| P55063 | Heat shock 70 kDa protein 1-like | Hspa1l | ↑ | 1.12 ± 0.02** | 1.09 ± 0.00** | 1.20 ± 0.04** |
| P63036 | DnaJ homolog subfamily A member 1 | Dnaja1 | ↓ | 0.7 ± 0.04** | 0.63 ± 0.17** | 0.75 ± 0.13* |
| Q62764 | Y-box-binding protein 3 | Ybx3 | ↓ | 0.7 ± 0.16* | 0.72 ± 0.13* | 0.59 ± 0.23** |
| Q64298 | Sperm mitochondrial-associated cysteine-rich protein | Smcp | ↓ | 0.82 ± 0.01 | 0.7 ± 0.33 | 0.65 ± 0.24* |
| Q66HD3 | Nuclear autoantigenic sperm protein | Nasp | ↑ | 1.19 ± 0.02* | 1.14 ± 0.10* | 1.22 ± 0.05** |
| Q68FX6 | Calcium-binding and spermatid-specific protein 1 | Cabs1 | ↑ | 1.18 ± 0.03* | 1.48 ± 0.11** | 1.49 ± 0.06** |
aThe change of protein expression level was expressed as a treated/control ratio (control = 1, mean ± SD). A value >1 represents up-regulation whereas a value <1 indicates down-regulation. *p < 0.05, **p < 0.01.