Fig. 2.

Acute effect of EL-17

(A) A paw pressure test was performed to evaluate the hypersensitivity to noxious mechanical stimuli. (B) Incapacitance test. The hind limb weight-bearing alterations were measured as postural imbalance related to pain. Data are expressed as the difference between the weight applied on the limb contralateral to the injury and the weight applied on the ipsilateral limb (Δweight). Measurements were performed on day 14 after CFA i.a. administration. EL-17 was suspended in 1% CMC and orally acutely administered and the pain threshold was evaluated over time. Control animals were treated with vehicle. The values represent the mean of eight rats performed in two different experimental sets. **P < 0.01 vs vehicle + vehicle–treated animals; ^†P < 0.05 and ^††P < 0.01 vs the pre-test (time 0 min) of the same group. CFA: Complete Freund’s Adjuvant; CMC: carboxymethylcellulose.