Fig. 3.

Preventive effect of EL-17

(A) Paw pressure test: response to noxious mechanical stimuli. (B) Von Frey test: withdrawal latency to a non-noxious mechanical stimulus. (C) Incapacitance test: hind limb weight-bearing alterations evaluated as postural imbalance related to pain (Δweight, expressed as the difference between the weight applied on the limb contralateral to the injury and the weight applied on the ipsilateral limb). EL-17 (10 and 30 mg/kg) was suspended in 1% CMC and orally daily administered starting on the day of CFA i.a. injection. Measurements were performed on days 7 and 14. Control animals were treated with vehicle. The values represent the mean of eight rats performed in two different experimental sets. **P < 0.01 vs vehicle + vehicle–treated animals; ^††P < 0.01 vs CFA + vehicle–treated animals. CFA: Complete Freund’s Adjuvant; CMC: carboxymethylcellulose.