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. 2016 Sep 1;14(1):254. doi: 10.1186/s12967-016-1017-3

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© The Author(s) 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — A representative tracing a showing the effect of norepinephrine (NE), acetylcholine (Ach), and different doses of crude extract of U. dioica (Ud.Cr) on mean arterial pressure (MAP) in normotensive rats under anesthesia. b The hypertensive and hypotensive effects of norepinephrine (NE) and acetylcholine (ACh), respectively. c The blood pressure of normotensive and hypertensive rats. d The effect of crude extract of U. dioica (Ud.Cr) on MAP in normotensive and hypertensive rats, under anesthesia (n = 6–7), *p < 0.05, **p < 0.01, and ***p < 0.001 represent the significance difference between the % fall in MAP on normotensive and hypertensive rats