Table 3.

Pathways that are enriched for the top ranked drug target genes

Pathway	Description [33]
BIOCARTA_IGF1_PATHWAY	Stimulates cell growth and blocks apoptosis
BIOCARTA_INSULIN_PATHWAY	Regulation of glucose levels
BIOCARTA_NGF_PATHWAY	Nerve growth factor pathway
BIOCARTA_TRKA_PATHWAY	Nerve growth factor receptor signaling pathway
REACTOME_ACTIVATION_OF_THE_AP1	Activation of the AP-1 family of transcription factors
_FAMILY_OF_TRANSCRIPTION_FACTORS
BIOCARTA_TFF_PATHWAY	Epithelial repair
BIOCARTA_LONGEVITY_PATHWAY	Involving age related diseases
REACTOME_SHC1_EVENTS_IN_EGFR
_SIGNALING	EGFR signaling
BIOCARTA_CBL_PATHWAY	Downregulate EGF receptors
BIOCARTA_CDK5_PATHWAY	Cellular proliferation and survival