Table 6.

Example sentences with PK DDI from literature

PMID	Study type	Sentence with DDI
10193676	in vivo	Both erythromycin and itraconazole increased the area under the lignocaine plasma concentration-time curve [AUC(0-infinity)] and lignocaine peak concentrations by 40-70 % (P<0.05).
10923859	in vitro	Rifalazil-25-deacetylation in microsomes was completely inhibited by diisopropyl fluorophosphate, diethyl p-nitrophenyl phosphate and eserine, but not by p-chloromercuribenzoate or 5,5′-dithio-bis(2-nitrobenzoic acid), indicating that the enzyme responsible for the rifalazil-25-deacetylation is a B-esterase.

The drug names involved in a PK DDI relation in each example are bolded