FIG. 5.

Effect of acute di(2-ethylhexyl) phthalate (DEHP) exposure on atresia and corpora lutea numbers at 9 months postdosing. Adult CD-1 mice were orally dosed with vehicle (tocopherol-stripped corn oil) or DEHP (20 µg/kg/day–500 mg/kg/day) daily for 10 days. Following 9 months postdosing, ovaries were processed for histological evaluation of antral follicle atresia (panel A) and corpora lutea numbers (panel B). Graphs represent means ± SEM (n = 4–6 ovaries/treatment group). Asterisks (*) represent significant difference from vehicle control (P ≤ 0.05).