Table 2.
Weighted means | p | ||||
---|---|---|---|---|---|
Variable | Auto-HSCT | 10/10 UD-HSCT | 9/10 UD-HSCT | 10/10 UD-HSCT vs auto-HSCT | 9/10 UD-HSCT vs auto-HSCT |
Global population | |||||
Median age at transplant, years | 47 | 46 | 47 | 0.84 | 1.00 |
Median year of transplant | 2008 | 2008 | 2008 | 0.66 | 0.88 |
Median interval diagnosis transplant (days) | 178 | 179 | 179 | 0.80 | 0.49 |
Good-risk cytogenetics (%) | 33 | 31 | 30 | 1.00 | 1.00 |
Poor-risk cytogenetics (%) | 15 | 17 | 19 | 1.00 | 1.00 |
More than 1 induction to achieve CR1 (%) | 16 | 18 | 17 | 0.7 | 0.91 |
By cytogenetic risk | |||||
Good risk | |||||
Median age at transplant, years | 44 | 44 | n.a.a | 0.96 | n.a. |
Median year of transplant | 2009 | 2009 | n.a. | 0.56 | n.a. |
Median interval diagnosis transplant (days) | 186 | 188 | n.a. | 1.00 | n.a. |
More than 1 induction to achieve CR1 (%) | 0.01 | 0.09 | n.a. | 0.84 | n.a. |
Intermediate risk | |||||
Patient age (years) | 48 | 48 | 49 | 0.96 | 0.39 |
Year of transplant | 2008 | 2008 | 2008 | 0.36 | 0.83 |
Interval diagnosis transplant (days) | 174 | 181 | 183 | 0.51 | 0.90 |
More than 1 induction to achieve CR1 (%) | 19 | 22 | 17 | 0.36 | 0.91 |
Intermediate-risk wtFLT3 | |||||
Patient age (years) | 46 | 48 | n.a. | 0.75 | n.a. |
Year of transplant | 2008 | 2009 | n.a. | 0.46 | n.a. |
Interval diagnosis transplant (days) | 118 | 115 | n.a. | 0.93 | n.a. |
More than 1 induction to achieve CR1 (%) | 17 | 21 | n.a. | 0.81 | n.a. |
Poor risk | |||||
Patient age (years) | 50 | 50 | 50 | 1.00 | 0.93 |
Year of transplant | 2008 | 2008 | 2009 | 0.87 | 0.11 |
Interval diagnosis transplant (days) | 172 | 170 | 173 | 1.00 | 0.91 |
More than 1 induction to achieve CR1 (%) | 24 | 25 | 27 | 0.81 | 0.77 |
Legend: ATT average treatment effect among the treated, CR1 first complete remission, wtFLT3 wild-type FLT3
aIn good risk and intermediate wtFLT3 categories, only auto-HSCT and 10/10 UD-HSCT were analyzed, as the number of 9/10 UD-HSCT transplants resulted too limited