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. 2016 Sep 2;9(1):79. doi: 10.1186/s13045-016-0314-x

Table 2.

ATT-weighted means for transplant groups

Weighted means p
Variable Auto-HSCT 10/10 UD-HSCT 9/10 UD-HSCT 10/10 UD-HSCT vs auto-HSCT 9/10 UD-HSCT vs auto-HSCT
Global population
 Median age at transplant, years 47 46 47 0.84 1.00
 Median year of transplant 2008 2008 2008 0.66 0.88
 Median interval diagnosis transplant (days) 178 179 179 0.80 0.49
 Good-risk cytogenetics (%) 33 31 30 1.00 1.00
 Poor-risk cytogenetics (%) 15 17 19 1.00 1.00
 More than 1 induction to achieve CR1 (%) 16 18 17 0.7 0.91
By cytogenetic risk
 Good risk
  Median age at transplant, years 44 44 n.a.a 0.96 n.a.
  Median year of transplant 2009 2009 n.a. 0.56 n.a.
  Median interval diagnosis transplant (days) 186 188 n.a. 1.00 n.a.
  More than 1 induction to achieve CR1 (%) 0.01 0.09 n.a. 0.84 n.a.
 Intermediate risk
  Patient age (years) 48 48 49 0.96 0.39
  Year of transplant 2008 2008 2008 0.36 0.83
  Interval diagnosis transplant (days) 174 181 183 0.51 0.90
  More than 1 induction to achieve CR1 (%) 19 22 17 0.36 0.91
 Intermediate-risk wtFLT3
  Patient age (years) 46 48 n.a. 0.75 n.a.
  Year of transplant 2008 2009 n.a. 0.46 n.a.
  Interval diagnosis transplant (days) 118 115 n.a. 0.93 n.a.
  More than 1 induction to achieve CR1 (%) 17 21 n.a. 0.81 n.a.
 Poor risk
  Patient age (years) 50 50 50 1.00 0.93
  Year of transplant 2008 2008 2009 0.87 0.11
  Interval diagnosis transplant (days) 172 170 173 1.00 0.91
  More than 1 induction to achieve CR1 (%) 24 25 27 0.81 0.77

Legend: ATT average treatment effect among the treated, CR1 first complete remission, wtFLT3 wild-type FLT3

aIn good risk and intermediate wtFLT3 categories, only auto-HSCT and 10/10 UD-HSCT were analyzed, as the number of 9/10 UD-HSCT transplants resulted too limited