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. 2016 Sep 1;18:194. doi: 10.1186/s13075-016-1092-0

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Expanding versus collapsed popliteal LNs in early versus late-stage RA knee flare. MRIs were obtained from RA patients with new-onset (a,b) and long-standing (>20 years) (c,d) asymmetric knee flare, who were enrolled in a phase 4 clinical trial to assess the effects of anti-TNF therapy on PLN volume (ClinicalTrials.gov NCT01098201). The 2D sagittal views (a,c) and 3D volume renderings (b,d) illustrate the dramatic differences between early RA flare with expanded PLN (pink, green and yellow arrows corresponding to pseudocolored PLN) adjacent to highly inflamed synovium and focal erosions in the lateral femoral condyle (*), compared with the barely visible collapsed PLN (blue and yellow arrows corresponding to pseudocolored PLN) adjacent to advanced pannus tissue and extensive bone erosions