Table 1. Characteristics of the topologically sensitive gene clusters.

					Size
Druga	Responseb	Cluster	Gene range (spr codes)	DEGsc	(No of genes)	(kb)	P value
NOV	U	1	2022−0017	34	42	21.11	8.4E−10
	U	2	0129−0161	30	33	31.78	4.1E−10
	U	3	0416−0484	44	69	71.88	1.2E−8
	U	4	0703−0721	12	19	19.12	6.9E−3
	U	5	1515−1536	17	22	24.69	4.8E−5
	U	6	1762−1775	11	14	13.61	1.8E−3
	U	7	1877−1888	9	12	16.51	1.2E−2
	D	8	0027−0042	12	16	12.62	1.0E−3
	D	9	0232−0277	33	45	48.11	4.7E−8
	D	10	0856−0884	21	29	23.54	1.2E−5
	D	11	1036−1048	8	13	23.91	4.1E−2
	D	12	1131−1145	12	15	11.15	7.0E−4
	D	13	1310−1325	14	16	11.77	4.9E−5
	D	14	1397−1408	9	12	15.81	1.2E−2
	D	15	1485−1498	12	14	15.99	4.0E−4
	D	16	1669−1687	15	19	16.99	2.0E−4
SCN	U	1	2040−0019	18	26	21.65	2.0E−4
	U	2	0342−0355	12	14	6.87	4.0E−4
	U	3	0628−0639	11	12	8.59	6.0E−4
	U	4	0744−0754	11	11	6.68	2.0E−4
	U	5	1750−1777	22	28	31.38	2.4E−6
	U	6	1876−1888	10	13	22.00	4.8E−3
	U	7	2002−2013	11	11	11.25	2.0E−4
	D	8	0254−0266	9	13	12.51	1.5E−2
	D	9	0314−0327	12	14	17.11	4.0E−4
	D	10	1129−1142	10	14	11.05	6.3E−3
	D	11	1314−1323	10	10	7.78	7.0E−4
	D	12	1353−1366	12	14	11.42	4.0E−4

^aNOV, novobiocin. SCN, seconeolitsine.

^bU, genes were up-regulated. D, genes were down-regulated.

^cDEGs included were those showing significant fold variations. These variations were detected either in microarrays (≥2 and P <0.05) or by RNA-Seq methods (≥1.8 and P <1E-14).