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| Survival rate | ||||
|---|---|---|---|---|
| CNNNG target | MegaTev-WT (n = 3) | R4 population | Mutants | # clones |
| CAAGG | 1.6 ± 0.8 | 16 | Q158R | 4 |
| K26R/Q158R | 1 | |||
| CCCCG | <0.1 | 36 | T95S | 5 |
| CGAAG | 13.5 ± 6.1 | 61 | Q158R | 5 |
| CGCCG | <0.1 | 20 | I86V/T95S | 1 |
| C39R/T95S | 2 | |||
| C39R/I86V/T95S | 3 | |||
| CGGAG | <0.1 | 29 | T95S | 3 |
| K26R/T95S | 2 | |||
| CTGGG | <0.1 | 37 | T95S | 3 |
| K26R/T95S | 2 | |||
